The main difference between the two is the orientation of the instrument. A standard electric guitar is designed to be played with the right hand on the fretboard and the left hand on the strumming/picking area, while a left-handed electric guitar is designed to be played with the left hand on the fretboard and the right hand on the strumming/picking area.
This means that the strings and pickups on a left-handed electric guitar are reversed, as are the position markers on the fretboard. Left-handed electric guitars are less common than right-handed guitars and may be more difficult to find in music stores.
It's important to note that some left-handed guitarists may choose to learn to play a standard right-handed guitar instead of a left-handed guitar. This can be a matter of personal preference or may be due to the availability of instruments. It's worth noting that this approach can be challenging at first, as it requires the left hand to perform more complex movements on the fretboard. However, with practice and dedication, many left-handed guitarists have been successful in learning to play a right-handed guitar.